This method will walk you through applying several Excel functions to generate lottery numbers. And you can do as follows:

1. In a blank worksheet, type column headers in Range A1:C1 as below screen shot shown:

2. Enter formulas in Column A, Column B, and Column C:

(1) In Cell A2, enter the formula =RAND(), and then drag the Fill handle to the range A2:A50.
(2) In Cell B2, enter the formula =RANK($A2,$A$2:$A$50)+COUNTIF(B$1:B1,B1)-1, and then drag the Fill Handle to the Range B2:B50. (In the formula, A2 is the random number left to current cell, $A$2:$A$50 are all random numbers we got with the first formula, B$1 is the first cell in Column B, and B1 is the cell above current cell).
(3) In Range C2:C50, enter sequence numbers from 1 to 49.

Then you will get a table as left screen shot shown:

 

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3. Find a blank range, type sequence numbers horizontally in a row as below screen shot shown:

4. Below the first sequence number of 1, enter the formula =VLOOKUP(G1,$B$1:$C$50,2,FALSE) into it, and the drag the Fill Handle to the Range you need.

Note: In this formula, G1 is the cell with the first sequence number of 1, $B$1:$C$50 are Unique Rank column and Ball Number column, 2 means find values in the second column of Range $B$1:$C$50.

Then you will get the lottery numbers as below screen shot shown:

5. It's optional. To prevent the lottery numbers from changing automatically when current worksheet refreshes, you can click the Formula > Calculation Options > Manual.

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Kutools for Excel’s List All Combinations utility is designed to general all possible combinations from several given series of data, and list these combinations in a column as below screenshot shown.

This method will guide you to apply a VBA macro to generate lottery numbers in Excel. Please do as follows:

1. Press Alt + F11 keys to open the Microsoft Visual Basic for Applications window.

2. Click Insert > Module to open a new module window, and paste following VBA code into it:

VBA: Lottery Number Generator in Excel

Sub LotteyCode()
Dim Rng As Range
Dim WorkRng As Range
Dim xNumbers(49) As Integer
On Error Resume Next
xTitleId = "KutoolsforExcel"
Set WorkRng = Application.Selection
Set WorkRng = Application.InputBox("Out put to (single cell):", xTitleId, WorkRng.Address, Type:=8)
Set WorkRng = WorkRng.Range("A1")
For xIndex = 1 To 49
xNumbers(xIndex) = xIndex
Next
For xIndex = 1 To 6
xNum = 1 + Application.Round(Rnd * (49 - xIndex), 0)
WorkRng.Offset(0, xIndex - 1).Value = xNumbers(xNum)
xNumbers(xNum) = xNumbers(50 - xIndex)
Next
End Sub

3. Press the F5 key or click the Run button to run this VBA macro.

4. Now in the popping up dialog box, specify a cell to output the lottery numbers, and click the OK button.

Then you will see 6 unique lottery numbers are generated and displayed in the specified cells.

If you have Kutools for Excel installed, its Insert Random Data utility can help you generate lottery numbers in Excel at once.

1. Select 6 adjacent cells, such as A1:F1, and then click the Kutools > Insert > Insert Random Data.

2. Now the Insert Random Data dialog box comes out. Go to the Integer tab, type 1 in From box, type 49 in To box, check the Unique values option, and click the OK button. Now you will see 6 unique lottery numbers are generated and displayed in the selected cells immediately.

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